LRP5 and LRP6 are important modulators of the WNT signaling pathway which is critical for bone growth and turnover. Mutations in the LRP5 and LRP6 genes cause a rare human genetic disorder of high bone mass. Division of Bone and Mineral Diseases faculty Steven Mumm, PhD, has been awarded a $433,125 two-year grant by the NIH-NIAMS to study the mechanisms of these disorders. He will develop patient-derived induced pluripotent stem cells to further assess how LRP5 and LRP6 mutations disrupt the WNT signaling pathway. Results of this study may help guide future treatment of these disorders and more common bone diseases like osteoporosis.