The Clinical Research Unit (CRU) of the Division of Bone and Mineral Diseases supports investigators with projects requiring assessment of clinically relevant bone outcomes and offers assistance with research subject recruitment and study management.

Established by Louis V. Avioli, MD, and currently directed by Roberto Civitelli, MD, the CRU participates in clinical trials evaluating the efficacy of novel osteoporosis therapies. The unit performs Phase II through Phase IV clinical trials and assists in investigator-initiated federally-sponsored patient research.

Available to investigators are state-of-the-art bone imaging technologies, including dedicated dual-energy X-ray absorptiometry (DXA) units for assessment of bone mineral density and body composition, and a high-resolution peripheral quantitative computed tomography (HRpQCT) scanner for assessment of bone microstructure and strength.

The CRU has been in operation for over twenty years and its services and resources are available to investigators outside the division, on a fee-for-service basis.


  • Center for Advanced Medicine, 11th floor, next to the Center for Clinical Studies
    4921 Parkview Place
    St. Louis, MO 63110
  • HRpQCT located at Center for Advanced Medicine – South County
    5201 Midamerica Plaza
    St. Louis, MO 63129


For more information about current clinical studies or on how to get involved in clinical research, please contact:

Bridgett Toennies, RT
Clinical Research Coordinator