Jianqiu Xiao PhD, Chun Wang MD, PhD, Gabriel Mbalaviele PhD, and colleagues, published a paper in PLOS Biology in which they show that pyroptosis mediated by the pore-forming protein gasdermin D plays a crucial role in the pathogenesis of a severe genetic autoinflammatory disorder known as neonatal-onset multisystem inflammatory disease.
Citation: Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice. Xiao J, Wang C, Yao JC, Alippe Y, Xu C, Kress D, Civitelli R, Abu-Amer Y, Kanneganti TD, Link DC, Mbalaviele G. PLoS Biol. 2018 Nov 2;16(11):e3000047. doi: 10.1371/journal.pbio.3000047. [Epub ahead of print]. PMID: 30388107vvvv