Daniel Warren, PhD Associate Professor Department of Biology Saint Louis University St. Louis, MO “Bone as a buffer: Insights from acidosis-tolerant turtles”   Please email Christina Grantham (granthamc@wustl.edu) for Zoom meeting ID and password.

Jennifer Brazill Nociceptive nerves regulate haematopoietic stem cell mobilization. (.pdf) Gao X, Zhang D, Xu C, Li H, Caron KM, Frenette PS. Nature. 2021 Jan;589(7843):591-596.   Schedule of presenters Please email Christina Grantham (granthamc@wustl.edu) for Zoom information.

Short Talks by Musculoskeletal Research Center Award Recipients and Trainees: Nelson Membreno PhD Student, Warren Lab, Department of Biology, Saint Louis University School of Medicine “TBA” Arin Oestreich, PhD Postdoctoral Research Associate, Guilak Lab, Orthopaedic Surgery “Maternal obesity and the developmental origins of osteoarthritis” Christopher Chermside-Scabbo MSTP Student, Silva Lab, Orthopaedic Surgery “Restoring the Mechanoresponsiveness […]

Kunjan Khanna The ubiquitylation of IL-1β limits its cleavage by caspase-1 and targets it for proteasomal degradation. (.pdf) Vijayaraj SL, Feltham R, Rashidi M, Frank D, Liu Z, Simpson DS, Ebert G, Vince A, Herold MJ, Kueh A, Pearson JS, Dagley LF, Murphy JM, Webb AI, Lawlor KE, Vince JE. Nat Commun. 2021 May 11;12(1):2713. […]

Roberto Civitelli  An osteocalcin-deficient mouse strain without endocrine abnormalities. (.pdf) Diegel CR, Hann S, Ayturk UM, Hu JCW, Lim KE, Droscha CJ, Madaj ZB, Foxa GE, Izaguirre I, Transgenics Core VVA, Paracha N, Pidhaynyy B, Dowd TL, Robling AG, Warman ML, Williams BO. PLoS Genet. 2020 May 28;16(5):e1008361. AND Osteocalcin is necessary for the alignment […]

Suresh Adapala Plasma cells promote osteoclastogenesis and periarticular bone loss in autoimmune arthritis. (.pdf) Komatsu N, Win S, Yan M, Huynh NC, Sawa S, Tsukasaki M, Terashima A, Pluemsakunthai W, Kollias G, Nakashima T, Takayanagi H. J Clin Invest. 2021 Mar 15;131(6):e143060.   Schedule of presenters Email Christina Grantham (granthamc@wustl.edu) for Zoom meeting information.

Wei Zou A mechanosensitive peri-arteriolar niche for osteogenesis and lymphopoiesis. (.pdf) Shen B, Tasdogan A, Ubellacker JM, Zhang J, Nosyreva ED, Du L, Murphy MM, Hu S, Yi Y, Kara N, Liu X, Guela S, Jia Y, Ramesh V, Embree C, Mitchell EC, Zhao YC, Ju LA, Hu Z, Crane GM, Zhao Z, Syeda R, […]

Nitin Pokhrel The bone microenvironment invigorates metastatic seeds for further dissemination. (.pdf) Zhang W, Bado IL, Hu J, Wan YW, Wu L, Wang H, Gao Y, Jeong HH, Xu Z, Hao X, Lege BM, Al-Ouran R, Li L, Li J, Yu L, Singh S, Lo HC, Niu M, Liu J, Jiang W, Li Y, Wong […]

Ariella Coler-Reilly LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss. (.pdf) Liu F, Yuan Y, Bai L, Yuan L, Li L, Liu J, Chen Y, Lu Y, Cheng J, Zhang J. Redox Biol. 2021 Jul;43:101963.   Schedule of presenters Email Christina Grantham (granthamc@wustl.edu) for Zoom meeting […]

Gabriel Mbalaviele β2-microglobulin triggers NLRP3 inflammasome activation in tumor-associated macrophages to promote multiple myeloma progression (.pdf) Hofbauer D, Mougiakakos D, Broggini L, Zaiss M, Büttner-Herold M, Bach C, Spriewald B, Neumann F, Bisht S, Nolting J, Zeiser R, Hamarsheh S, Eberhardt M, Vera J, Visentin C, De Luca CMG, Moda F, Haskamp S, Flamann C, […]

Ganesh Raut Osteoclasts protect bone blood vessels against senescence through the angiogenin/plexin-B2 axis. (.pdf) Liu X, Chai Y, Liu G, Su W, Guo Q, Lv X, Gao P, Yu B, Ferbeyre G, Cao X, Wan M. Nat Commun. 2021 Mar 23;12(1):1832.   Schedule of presenters (.pdf) Please email Christina Grantham (granthamc@wustl.edu) for Zoom meeting information.

Dan Warren Distinct roles for the hypoxia-inducible transcription factors HIF-1α and HIF-2α in human osteoclast formation and function. (.pdf) Knowles HJ. Sci Rep. 2020 Dec 3;10(1):21072.   Schedule of presenters (.pdf) Please email Christina Grantham (granthamc@wustl.edu) for Zoom meeting information.

Mohamed Hassan BMPR1A maintains skeletal stem cell properties in craniofacial development and craniosynostosis. (.pdf) Maruyama T, Stevens R, Boka A, DiRienzo L, Chang C, Yu HI, Nishimori K, Morrison C, Hsu W. Sci Transl Med. 2021 Mar 3;13(583):eabb4416.   Schedule of presenters (.pdf) Please email Christina Grantham (granthamc@wustl.edu) for Zoom meeting information.

Chun Wang IL-1β-driven osteoclastogenic Tregs accelerate bone erosion in arthritis. (.pdf) Levescot A, Chang MH, Schnell J, Nelson-Maney N, Yan J, Martínez-Bonet M, Grieshaber-Bouyer R, Lee PY, Wei K, Blaustein RB, Morris A, Wactor A, Iwakura Y, Lederer JA, Rao DA, Charles JF, Nigrovic PA. J Clin Invest. 2021 Sep 15;131(18):e141008.   Schedule of presenters […]