Michael Whyte, MD

Professor of Medicine, Pediatrics and Genetics

Dr. Michael Whyte earned his MD degree at Downstate College of Medicine, State University of New York, Brooklyn, NY, and then had residency training in Internal Medicine at Bellevue Hospital in New York City. After his fellowship in Endocrinology, he joined the faculty of our Division in the late 1970s. Dr. Whyte is a world-leading expert in heritable skeletal disorders in children and adults. He directs the Center for Metabolic Bone Disease and Molecular Research at Shriners Hospital for Children, St. Louis, which serves as a national resource for the diagnosis, treatment, and investigation of disorders of bone and mineral metabolism and skeletal dysplasias in children. In addition to his activities at Shriners Hospital, Dr. Whyte sees patients in the Bone Health Program at the Center for Advanced Medicine.

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Professional Societies and Organizations

  • American Board of Internal Medicine
  • American College of Endocrinology
  • American Federation of Clinical Research
  • American Society for Bone and Mineral Research
  • American Society for Cell Biology
  • American Society for Clinical Investigation
  • American Society for the Advancement of Science
  • American Society of Human Genetics
  • Association of American Physicians
  • The Endocrine Society
  • National Board of Medical Examiners
  • Society for Experimental Biology and Medicine

Recognition

  • Listed in Best Doctors in America, 2005 – 2009
  • Charles Slemenda Award, 5th International Conference on Children’s Bone Health, Cambridge, UK, 2009
  • Frederic C. Bartter Award, American Society for Bone and Mineral Research, 2007
  • Dr. Boy Frame Award, Adult Bone and Mineral Working Group, American Society for Bone and Mineral Research, 1997
  • Distinguished Medical Service Award, The Magic Foundation for Children’s Growth, 1996
  • Who’s Who in America, 1996
  • Who’s Who in Science and Engineering, 1996
  • Who’s Who in American Education, 1993
  • Fuller Albright Award, American Society for Bone and Mineral Research, 1987
  • Young Investigator Award, American Society for Bone and Mineral Research, 1983

Clinical Interests

  • Osteogenesis Imperfecta
  • Rickets
  • Osteopetrosis
  • Hypophosphatemia
  • Heritable Metabolic and Dysplastic Bone Diseases in Children

Research Interests

Dr. Whyte’s research interests include the cause and treatment of especially heritable skeletal disorders in children and adults. Included are genetic forms of rickets such as hypophosphatasia and X-linked hypophosphatemia, brittle bone diseases like osteogenesis imperfecta, and conditions that cause dense bones such as osteopetrosis. Collaborative laboratory investigations include mapping of specific diseases on human chromosomes and then searches for mutated genes. Molecular findings are then related to clinical observations to better understand how these conditions develop. The Research Center at Shriners Hospital serves as a national resource for the diagnosis, treatment, and investigation of disorders of bone and mineral metabolism and skeletal dysplasias in children. Dr. Whyte has authored or co-authored more than 300 scientific papers or book chapters concerning pediatric and adult metabolic bone diseases.

Publications

  • Whyte MP, Bergfeld M, Murphy WA, Avioli LV, Teitelbaum SL. Postmenopausal Osteoporosis: A Heterogeneous Disorder As Assessed By Histomorphometric Analysis Of Iliac Crest Bone From Untreated Patients. Am J Med. 1982 Feb; 72(2):193-202
  • Whyte MP, Mahuren DJ, Vrabel LA, Coburn SP. Markedly Increased Circulating Pyridoxal–5/–Phosphate Levels In Hypophosphatasia: Alkaline Phosphatase Acts In Vitamin B6 Metabolism. J Clin Invest. 1985 Aug;76 (2):752-6.
  • Whyte MP, Obrecht SE, Finnegan PM, Jones JL, Podgornik MN, McAlister WH, Mumm S. Osteoprotegerin Deficiency And Juvenile Paget’s Disease. N Engl J Med. 2002 Jul 18; 347(3): 175-84
  • Whyte MP, Kurtzburg J, McAlister WH, Podgornik MN, Mumm SR, Coburn SP, Ryan LM, Miller CR, Gottesman GS, Martin PL. Marrow Cell Transplantation For Infantile Hypophosphatasia. J Bone Miner Res. 2003 Apr; 18(4):624-36
  • Whyte MP, Wenkert D, Clements KL, McAlister WH, Mumm S. Bisphosphonate-induced osteopetrosis. N Egl J Med. 2003 Jul 31; 349(5):457-63.