Events at Conference Room AB, Steven & Susan Lipstein BJC Institute of Health

–

Jerry Xiang Bone degradation machinery of osteoclasts: An HIV-1 target that contributes to bone loss (.pdf) Raynaud-Messina B , Bracq L, Dupont M, Souriant S, Usmani SM, Proag A, Pingris K, Soldan V, Thibault C, Capilla F, Al Saati T, Gennero I, Jurdic P, Jolicoeur P, Davignon JL, Mempel TR, Benichou S, Maridonneau-Parini I, and […]

–

Mary Beth Humphrey, MD, PhD, FACP Professor of Medicine, McEldowney Chair in Immunology Chief, Division of Rheumatology, Immunology, and Allergy Department of Medicine University of Oklahoma Health Sciences Center, Oklahoma City, OK “Osteoimmunology: From Bench to Bedside” To watch the recorded presentation after the program »

–

Zhangting Yao Targeting cellular senescence prevents age-related bone loss in mice.(.pdf) Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S. Nat Med. 2017 Sep;23(9):1072-1079.

–

Jianqiu Xiao Chemical disruption of the pyroptotic pore-forming protein gasdermin D inhibits inflammatory cell death and sepsis. (.pdf) Rathkey JK, Zhao J, Liu Z, Chen Y, Yang J, Kondolf HC, Benson BL, Chirieleison SM, Huang AY, Dubyak GR, Xiao TS, Li X, Abbott DW. Sci Immunol. 2018 Aug 24;3(26). pii: eaat2738.

–

Sahil Mahajan Self-renewing resident cardiac macrophages limit adverse remodeling following myocardial infarction. (.pdf) Dick SA, Macklin JA, Nejat S, Momen A, Clemente-Casares X, Althagafi MG, Chen J, Kantores C, Hosseinzadeh S, Aronoff L, Wong A, Zaman R, Barbu I, Besla R, Lavine KJ, Razani B, Ginhoux F, Husain M, Cybulsky MI, Robbins CS, Epelman S. […]

–

Roberta Faccio Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. (.pdf) Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto […]

–

Yousef Abu-Amer Group 2 Innate Lymphoid Cells Attenuate Inflammatory Arthritis and Protect from Bone Destruction in Mice. (.pdf) Omata Y, Frech M, Primbs T, Lucas S, Andreev D, Scholtysek C, Sarter K, Kindermann M, Yeremenko N, Baeten DL, Andreas N, Kamradt T, Bozec A, Ramming A, Krönke G, Wirtz S, Schett G, Zaiss MM Cell […]

–

Gregg Fox Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. (.pdf) Lee J, Yesilkanal AE, Wynne JP, Frankenberger C, Liu J, Yan J, Elbaz M, Rabe DC, Rustandy FD, Tiwari P, Grossman EA, Hart PC, Kang C, Sanderson SM, Andrade J, Nomura DK, Bonini MG, Locasale JW, Rosner MR Nature. 2019 Apr;568(7751):254-258

–

Ji Woong Park Inhibition of Mevalonate Pathway Prevents Adipocyte Browning in Mice and Men by Affecting Protein Prenylation. (.pdf) Balaz M, Becker AS, Balazova L, Straub L, Müller J, Gashi G, Maushart CI, Sun W, Dong H, Moser C, Horvath C, Efthymiou V, Rachamin Y, Modica S, Zellweger C, Bacanovic S, Stefanicka P, Varga L, […]

–

Biancamaria Ricci Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone metastasis. (.pdf) Esposito M, Mondal N, Greco TM, Wei Y, Spadazzi C, Lin SC, Zheng H, Cheung C, Magnani JL, Lin SH, Cristea IM, Sackstein R, Kang Y. Nat Cell Biol. 2019 May;21(5):627-639

–

Jingyu (Jerry) Xiang Dysregulated integrin αVβ3 and CD47 signaling promotes joint inflammation, cartilage breakdown, and progression of osteoarthritis. (.pdf) Wang Q, Onuma K, Liu C, Wong H, Bloom MS, Elliott EE, Cao RR, Hu N, Lingampalli N, Sharpe O, Zhao X, Sohn DH, Lepus CM, Sokolove J, Mao R, Cisar CT, Raghu H, Chu CR, […]

–

Zhangting Yao Microenvironmental IL1β promotes breast cancer metastatic colonisation in the bone via activation of Wnt signalling. (.pdf) Eyre R, Alférez DG, Santiago-Gómez A, Spence K, McConnell JC, Hart C, Simões BM, Lefley D, Tulotta C, Storer J, Gurney A, Clarke N, Brown M, Howell SJ, Sims AH, Farnie G, Ottewell PD, Clarke RB. Nat […]