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Gabriel Mbalaviele, PhD

Professor of Medicine

Phone314-286-1114

Fax314-454-5047

Emailgmbalaviele@wustl.edu

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Recognition

Pfizer Individual Performance Awards, 2005-2010
Pfizer Outstanding Publication Award, 2009
Advances in Mineral Metabolism Award, American Society for Bone and Mineral Research, 1998
John Haddad Young Investigator Award, American Society for Bone and Mineral Research, 1998
Procter and Gamble Young Investigator Award, American Society for Bone and Mineral Research, 1994
ASBMR Travel Award, American Society for Bone and Mineral Research, 1989
Merit Scholarship, French Association for Prevention and Treatment of Decalcification, 1987-1992
Co-holder of 5 patents
Professional Societies and Organizations
American Society for Bone and Mineral Research
Federation of American Societies for Experimental Biology
Advances in Mineral Metabolism

Research Interests

Dr. Mbalaviele’s research interests focus on signaling pathways activated by inflammatory mediators as applied to age-related bone loss.

Publications

Mnich SJ, Blanner PM, Hu LG, Shaffer AF, Happa FA, O’Neil S, Ukairo O, Weiss D, Welsh E, Storer C, Mbalaviele G, Ichijo H, Monahan JB, Hardy MM, Eda H. Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis. Int Immunopharmacol. 2010 Jul 6. (In Press)
Di Benedetto A, Watkins M, Grimston S, Salazar V, Donsante C, Mbalaviele G, Radice GL, Civitelli R. N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms. J Cell Sci. 2010 Jul 6. (In Press)
Mathialagan S, Poda GI, Kurumbail RG, Selness SR, Hall T, Reitz BA, Weinberg RA, Kishore N, Mbalaviele G. Expression, purification and functional characterization of IkappaB kinase-2 (IKK-2) mutants. Protein Expr Purif. 2010 Aug;72(2):254-61. Epub 2010 Feb 20.
Baima ET, Guzova JA, Mathialagan S, Nagiec EE, Hardy MM, Song LR, Bonar SL, Weinberg RA, Selness SR, Woodard SS, Chrencik J, Hood WF, Schindler JF, Kishore N, Mbalaviele G. Novel insights into the cellular mechanisms of the anti-inflammatory effects of NF-kappaB essential modulator binding domain peptides. J Biol Chem. 2010 Apr 30;285(18):13498-506. Epub 2010 Feb 18.
Mbalaviele G, Pauley A, Shaffer A, Zweifel B, Mathialagan S, Mnich S, Nemirovskiy O, Carter J, Gierse J, Wang J, Vazquez M, Moore W, Masferrer J, Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor, Biochem Pharmacol. 2010 May 15;79(10):1445-54. Epub 2010 Jan 11.

Editorial Responsibilities

Reviewer: Stem Cells, Journal of Experimental Pharmacology